Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 15/20 | 0.52 |
| ▸ | CDK8 | P49336 | 15/20 | 0.52 |
| ▸ | MET | P08581 | 2/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20733006 | 0.85 | CCNC (0.51) | CCNCCDK8MKNK1MKNK2ACVR1 | |
| SCHEMBL17437027 | 0.82 | CCNC (0.70) | CCNCCDK8MET | |
| SCHEMBL28905760 | 0.81 | CCNC (0.50) | CCNCCDK8MKNK1MKNK2ACVR1 | |
| SCHEMBL22070452 | 0.81 | CCNC (0.48) | CCNCCDK8ACVR1 | |
| SCHEMBL20732932 | 0.81 | CCNC (0.57) | CCNCCDK8MKNK1MKNK2 | |
| SCHEMBL20732965 | 0.78 | CCNC (0.54) | CCNCCDK8MKNK1MKNK2 | |
| SCHEMBL20732992 | 0.78 | CCNC (0.57) | CCNCCDK8METACVR1 | |
| SCHEMBL22070425 | 0.77 | CCNC (0.48) | CCNCCDK8ACVR1 | |
| SCHEMBL20732991 | 0.76 | CCNC (0.62) | CCNCCDK8 | |
| SCHEMBL20732929 | 0.76 | CCNC (0.64) | CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3666770-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS CDK8/19 INHIBITORS | Joint Stock Company "Biocad" (RU) | 2020-06-17 | — | — | EP | disclosed |
| WO-2019031990-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS CDK8/19 INHIBITORS | ЗАКРЫТОЕ АКЦИОНЕРНОЕ ОБЩЕСТВО "БИОКАД" | 2019-02-14 | — | — | WO | disclosed |