Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGK1 | O00141 | 1/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NEK1 | Q96PY6 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20733018 | 0.85 | SGK1 (0.44) | SGK1CAMKK2SLC2A1EGFRALDH1A1 | |
| SCHEMBL20733083 | 0.78 | HPGD (0.59) | ALDH1A1KDM4EHPGDGAA | |
| SCHEMBL20733016 | 0.74 | MELK (0.42) | SGK1CAMKK2SLC2A1EGFRHPGD | |
| SCHEMBL31133491 | 0.72 | HTT (0.60) | ALDH1A1KDM4EHPGDMAPK1SMN1; SMN2 | |
| SCHEMBL18370114 | 0.72 | HTT (0.60) | ALDH1A1KDM4EHPGDMAPK1SMN1; SMN2 | |
| SCHEMBL10138348 | 0.71 | SLC22A12 (0.51) | SGK1CAMKK2SLC2A1EGFRSMN1; SMN2 | |
| SCHEMBL20733006 | 0.71 | CCNC (0.51) | — | |
| SCHEMBL21261147 | 0.69 | EGFR (0.62) | SLC2A1EGFRALDH1A1KDM4EMAPT | |
| SCHEMBL2247463 | 0.68 | ATM (0.65) | ALDH1A1KDM4EMAPK1GAATDP1 | |
| SCHEMBL6909201 | 0.68 | CA1 (0.58) | EGFRALDH1A1KDM4EMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3666770-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS CDK8/19 INHIBITORS | Joint Stock Company "Biocad" (RU) | 2020-06-17 | — | — | EP | disclosed |
| WO-2019031990-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS CDK8/19 INHIBITORS | ЗАКРЫТОЕ АКЦИОНЕРНОЕ ОБЩЕСТВО "БИОКАД" | 2019-02-14 | — | — | WO | disclosed |