Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 20/20 | 0.62 |
| ▸ | WDR77 | Q9BQA1 | 19/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20733643 | 0.77 | PRMT5 (0.62) | PRMT5WDR77 | |
| SCHEMBL29390536 | 0.76 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL20721439 | 0.76 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL32675123 | 0.76 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL20721555 | 0.76 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL29391763 | 0.76 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL20721437 | 0.76 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL32675142 | 0.76 | PRMT5 (1.00) | PRMT5WDR77 | |
| Hydrochloric Acid SCHEMBL29684140 | 0.76 | PRMT5 (0.98) | PRMT5WDR77 | |
| SCHEMBL20721401 | 0.74 | PRMT5 (0.73) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939986-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | Prelude Therapeutics, Incorporated (US) | 2022-01-19 | — | — | EP | disclosed |
| WO-2019032859-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2019-02-14 | — | — | WO | disclosed |