Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SELE | P16581 | 1/20 | 0.34 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12985435 | 0.86 | SLC22A12 (0.41) | SLC22A12FGFR1FGFR4PDE4APDE4B | |
| SCHEMBL12985353 | 0.86 | SLC22A12 (0.41) | SLC22A12FGFR1FGFR4PDE4APDE4B | |
| SCHEMBL16978036 | 0.86 | SLC22A12 (0.41) | SLC22A12FGFR1FGFR4PDE4APDE4B | |
| SCHEMBL16236565 | 0.83 | NPC1 (0.39) | SLC22A12LMNAENPP1FGFR1FGFR4 | |
| SCHEMBL4086353 | 0.83 | SLC22A12 (0.42) | ADORA2AADORA2BADORA1SLC22A12FGFR1 | |
| SCHEMBL16236766 | 0.82 | SLC22A12 (0.36) | SLC22A12FGFR1FGFR4PDE4APDE4B | |
| SCHEMBL16769961 | 0.81 | SLC22A12 (0.41) | ADORA2AADORA2BADORA1SLC22A12HTT | |
| SCHEMBL21943146 | 0.81 | ADORA2A (0.59) | ADORA2AADORA2BADORA1ADORA3RET | |
| SCHEMBL22399203 | 0.80 | SLC22A12 (0.43) | ADORA2AADORA2BADORA1SLC22A12HTT | |
| SCHEMBL100735 | 0.78 | SLC22A12 (0.37) | SLC22A12SELEVCAM1ENPP1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019032859-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2019-02-14 | — | — | WO | disclosed |