Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 8/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | CCR4 | P51679 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20733815 | 0.97 | CDK1 (0.45) | CDK1KDM4EGLAMEN1TSHR | |
| SCHEMBL20733875 | 0.81 | HRH4 (0.57) | CDK1KDM4ECCNE2CDK4CCND1 | |
| SCHEMBL20733814 | 0.78 | HRH4 (0.58) | CDK1KDM4ECCNE2CDK4CCND1 | |
| SCHEMBL20718973 | 0.78 | HRH4 (0.58) | CDK1KDM4ECCNE2CDK4CCND1 | |
| SCHEMBL2845074 | 0.76 | HRH4 (0.53) | CDK1KDM4ECCNE2CDK4CCND1 | |
| SCHEMBL3644297 | 0.76 | CDK1 (0.62) | CDK1KDM4EKMT2ACCNE2CDK4 | |
| SCHEMBL3644294 | 0.76 | CDK1 (0.62) | CDK1KDM4EKMT2ACCNE2CDK4 | |
| SCHEMBL20718970 | 0.75 | CCNE2 (0.62) | CDK1CCNE2CCNE1CDK2CDK5 | |
| SCHEMBL2852678 | 0.74 | HRH4 (0.51) | CDK1KDM4EKMT2ACCNE2CDK4 | |
| SCHEMBL2852687 | 0.74 | CCNE2 (0.49) | CDK1KDM4EGLAMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10815219-B2 | 2,4-diaminoquinazoline derivatives for inhibiting endoplasmic reticulum (ER) stress | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2020-10-27 | — | — | US | disclosed |
| US-20190047988-A1 | 2,4-DIAMINOQUINAZOLINE DERIVATIVES FOR INHIBITING ENDOPLASMIC RETICULUM (ER) STRESS | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA | 2019-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190047988-A1 | 2,4-DIAMINOQUINAZOLINE DERIVATIVES FOR INHIBITING ENDOPLASMIC RETICULUM (ER) STRESS | DDIT3, HSPA5, ERN2 | CDK1 1415/4885KDM4E 2175/4885GLA 3639/4885 |
| US-10815219-B2 | 2,4-diaminoquinazoline derivatives for inhibiting endoplasmic reticulum (ER) stress | DDIT3, HSPA5, ERN2 | CDK1 1415/4885KDM4E 2175/4885GLA 3639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.