SCHEMBL20733923

SCHEMBL20733923

COc1cc(OC)c(Cl)c(-c2cc3cnc(NC4CCOCC4)nc3n(CCCN3CCNCC3)c2=O)c1

nearest known ligand 0.79

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 20/20 0.79
FGFR2 P21802 13/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18501294 0.90 FGFR1 (0.86) FGFR1FGFR2
SCHEMBL20733972 0.90 FGFR1 (0.65) FGFR1FGFR2
SCHEMBL16993365 0.89 FGFR1 (1.00) FGFR1FGFR2
SCHEMBL16993240 0.87 FGFR1 (0.76) FGFR1FGFR2
SCHEMBL20733973 0.87 FGFR1 (0.81) FGFR1FGFR2
SCHEMBL21218254 0.86 FGFR1 (0.87) FGFR1FGFR2
SCHEMBL16997117 0.85 FGFR1 (1.00) FGFR1FGFR2
SCHEMBL16997141 0.85 FGFR1 (1.00) FGFR1FGFR2
SCHEMBL16993357 0.85 FGFR1 (1.00) FGFR1FGFR2
SCHEMBL16993287 0.83 FGFR1 (0.75) FGFR1FGFR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019029541-A1 FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITOR AND USE THEREOF 南京药捷安康生物科技有限公司 2019-02-14 WO disclosed