Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 20/20 | 0.91 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.75 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.75 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.75 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2072688 | 0.98 | HDAC1 (0.91) | HDAC1HDAC2HDAC3HDAC6 | |
| Trifluoroacetic Acid SCHEMBL2071171 | 0.96 | HDAC1 (0.91) | HDAC1HDAC2HDAC3HDAC6HDAC8 | |
| SCHEMBL15514069 | 0.95 | HDAC1 (1.00) | HDAC1HDAC2HDAC3HDAC6HDAC8 | |
| Hydrochloric Acid SCHEMBL15512805 | 0.94 | HDAC1 (0.98) | HDAC1HDAC2HDAC3HDAC6HDAC8 | |
| Hydrochloric Acid SCHEMBL2073552 | 0.94 | HDAC1 (0.98) | HDAC1HDAC2HDAC3HDAC6HDAC8 | |
| Trifluoroacetic Acid SCHEMBL2073933 | 0.94 | HDAC1 (0.91) | HDAC1HDAC2HDAC3HDAC6HDAC8 | |
| SCHEMBL15513210 | 0.94 | HDAC1 (1.00) | HDAC1HDAC2HDAC3HDAC6HDAC8 | |
| Trifluoroacetic Acid SCHEMBL2074723 | 0.93 | HDAC1 (0.89) | HDAC1HDAC2HDAC3HDAC6HDAC8 | |
| Trifluoroacetic Acid SCHEMBL2073472 | 0.93 | HDAC1 (0.79) | HDAC1HDAC2HDAC3HDAC6HDAC8 | |
| Trifluoroacetic Acid SCHEMBL2074304 | 0.93 | HDAC1 (0.89) | HDAC1HDAC2HDAC3HDAC6HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828171-B1 | HETEROCYCLE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2014-03-12 | — | — | EP | claimed |
| EP-1828171-B1 | HETEROCYCLE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2014-03-12 | — | — | EP | disclosed |
| US-7863294-B2 | Heterocycle derivatives as histone deacetylase (HDAC) inhibitors | INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-01-04 | — | — | US | disclosed |
| US-20090048228-A1 | Heterocycle Derivatives As Histone Deacetylase (Hdac) Inhibitors | MSD ITALIA S.R.L. (IT) | 2009-02-19 | — | — | US | disclosed |
| EP-1828171-A2 | HETEROCYCLE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006061638-A2 | HETEROCYCLE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2006-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048228-A1 | Heterocycle Derivatives As Histone Deacetylase (Hdac) Inhibitors | HDAC1, HDAC5, HDAC11 | HDAC1 1/4885HDAC2 10/4885HDAC3 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.