SCHEMBL20735692

SCHEMBL20735692

COc1ccc(NC(=O)Nc2cccc(C)c2)cc1-c1c(Cl)cnn1C

nearest known ligand 0.77

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 20/20 0.77
HTR2C P28335 20/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5061789 0.91 HTR2A (0.82) HTR2AHTR2C
SCHEMBL29572936 0.91 HTR2A (0.82) HTR2AHTR2C
SCHEMBL5056028 0.90 HTR2A (0.77) HTR2AHTR2C
SCHEMBL29573223 0.90 HTR2A (0.77) HTR2AHTR2C
SCHEMBL29572700 0.89 HTR2A (0.79) HTR2AHTR2C
SCHEMBL5063252 0.89 HTR2A (0.79) HTR2AHTR2C
SCHEMBL29572904 0.89 HTR2A (0.79) HTR2AHTR2C
SCHEMBL5061583 0.89 HTR2A (0.79) HTR2AHTR2C
SCHEMBL20735211 0.88 HTR2A (0.80) HTR2AHTR2C
SCHEMBL5063227 0.87 HTR2A (1.00) HTR2AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019033068-A1 USE OF 5HT2A INVERSE AGONISTS FOR TREATING PSYCHOSIS AXOVANT SCIENCES GMBH (CH) 2019-02-14 WO disclosed