Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.76 |
| ▸ | TEK | Q02763 | 10/20 | 0.76 |
| ▸ | LCK | P06239 | 7/20 | 0.76 |
| ▸ | SRC | P12931 | 6/20 | 0.76 |
| ▸ | EGFR | P00533 | 6/20 | 0.63 |
| ▸ | ABL1 | P00519 | 5/20 | 0.63 |
| ▸ | ABL2 | P42684 | 4/20 | 0.63 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.60 |
| ▸ | PRKDC | P78527 | 2/20 | 0.60 |
| ▸ | HCK | P08631 | 1/20 | 0.59 |
| ▸ | MTOR | P42345 | 1/20 | 0.59 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.59 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.59 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7007567 | 0.87 | KDR (0.71) | KDRTEKLCKSRCEGFR | |
| SCHEMBL29552512 | 0.86 | TEK (1.00) | KDRTEKLCKSRCEGFR | |
| SCHEMBL7005359 | 0.86 | TEK (1.00) | KDRTEKLCKSRCEGFR | |
| SCHEMBL7011622 | 0.85 | TEK (0.81) | KDRTEKLCKSRCEGFR | |
| SCHEMBL2075050 | 0.85 | KDR (0.56) | KDRTEKLCKSRCEGFR | |
| SCHEMBL7853816 | 0.84 | TEK (0.79) | KDRTEKLCKSRCEGFR | |
| SCHEMBL2074398 | 0.84 | PIK3CD (0.73) | KDRTEKLCKSRCEGFR | |
| SCHEMBL13020100 | 0.84 | KDR (0.68) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL2073439 | 0.84 | KDR (0.65) | KDRTEKLCKSRCEGFR | |
| SCHEMBL2074411 | 0.84 | TEK (0.78) | KDRTEKLCKSRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863444-B2 | 4-aminopyrrolopyrimidines as kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-01-04 | — | — | US | disclosed |
| US-20030187001-A1 | 4-AMINOPYRROLOPYRIMIDINES AS KINASE INHIBITORS | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2003-10-02 | — | — | US | disclosed |
| EP-0970084-B1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AG (DE) | 2003-06-04 | — | — | EP | disclosed |
| CN-1326457-A | 4-aminopyrrolopyrimidines as kinase inhibitors | BASF AG (DE) | 2001-12-12 | — | — | CN | disclosed |
| EP-0970084-A1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-01-12 | — | — | EP | disclosed |
| US-6001839-A | Substituted 4-amino-7H-pyrrolo [2,3,-d]-pyrimidines as PTK inhibitors | BASF AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | disclosed |
| WO-1998041525-A1 | PYRROLO[2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 1998-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187001-A1 | 4-AMINOPYRROLOPYRIMIDINES AS KINASE INHIBITORS | LCK, PPP5C, DUSP1 | KDR 140/4885TEK 199/4885LCK 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.