SCHEMBL207434

SCHEMBL207434

c1ncc2c[nH]cc2n1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL27258265 0.98 EGFR (0.45)
SCHEMBL28276523 0.98
Trifluoroacetic Acid SCHEMBL28162941 0.84 EGFR (0.35)
Quinazoline SCHEMBL27867944 0.77 EGFR (0.77)
SCHEMBL28842206 0.76 EGFR (0.37)
SCHEMBL11213155 0.71 EGFR (0.38)
SCHEMBL8874014 0.69 EGFR (0.58)
SCHEMBL29656511 0.69 EGFR (0.43)
SCHEMBL29504717 0.69 EGFR (0.43)
SCHEMBL137377 0.68 EGFR (0.60)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 269 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3883932-B1 INHIBITORS OF GLI1 AS THERAPEUTIC AGENTS UNIV NEW YORK (US) 2023-03-29 EP claimed
US-20220289753-A1 SHP2 INHIBITORS IRBM S.P.A. (IT) 2022-09-15 US claimed
CN-114728935-A SHP2 inhibitor IRBM股份公司 2022-07-08 CN claimed
EP-4010335-A1 SHP2 INHIBITORS IRBM S.P.A. (IT) 2022-06-15 EP claimed
WO-2021028362-A1 SHP2 INHIBITORS IRBM S.P.A. (IT) 2021-02-18 WO claimed
EP-3772513-A1 SHP2 INHIBITORS C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening (IT) 2021-02-10 EP claimed
CN-105008370-B tricyclic compounds as CFTR inhibitors 诺华股份有限公司 2017-06-09 CN claimed
CN-102238872-A Organic compounds INTRA CELLULAR THERAPIES INC 2011-11-09 CN claimed
US-7935824-B2 Ethylenediamine derivatives DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2011-05-03 US claimed
EP-1720878-A1 HETEROARYL-FUSED PYRAZOLO DERIVATIVES F.HOFFMANN-LA ROCHE AG (CH) 2006-11-15 EP claimed
WO-2005085248-A1 HETEROARYL-FUSED PYRAZOLO DERIVATIVES F.HOFFMANN-LA ROCHE AG (CH) 2005-09-15 WO claimed
US-6140033-A SUPPORT WITH SILVER HALIDE EMULSIONS WITH COUPLERS EASTMAN KODAK COMPANY (US) 2000-10-31 US claimed
EP-1014185-A1 Photographic element, pyrazolazole coupler, method for it's preparation and an azomethine dye EASTMAN KODAK COMPANY (US) 2000-06-28 EP claimed
CN-1258021-A Photographic material EASTMAN KODAK CO (US) 2000-06-28 CN claimed
EP-0496617-B1 Adenosine kinase inhibitors METABASIS THERAPEUTICS INC (US) 1999-12-01 EP claimed
EP-0055562-B1 CEPHALOSPORIN DERIVATIVES ICI PHARMA (FR) 1986-02-12 EP claimed
US-20260138970-A1 MODULATORS OF THE CALCIUM SIGNALING CASCADE FONDAZIONE TELETHON ETS (IT) 2026-05-21 US disclosed
WO-2026103730-A1 DIAZAHETEROCYCLIC DERIVATIVE OF PYRIDOARYL GROUP HAVING KAPPA RECEPTOR ANTAGONISTIC ACTIVITY AND COMPOSITION THEREOF, AND USE 江苏恩华药业股份有限公司 2026-05-21 WO disclosed
EP-0055562-B1 CEPHALOSPORIN DERIVATIVES ICI PHARMA (FR) 1986-02-12 EP disclosed
US-4010159-A Pyrrolo[3,4-d]pyrimidines and methods for their preparation GRUPPO LEPETIT S.P.A. (IT) 1977-03-01 US disclosed