Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20972639 | 0.85 | USP2 (0.46) | — | |
| SCHEMBL20972642 | 0.85 | USP2 (0.46) | — | |
| SCHEMBL20972701 | 0.76 | KDM4E (0.32) | KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL20745643 | 0.76 | KDM4E (0.32) | KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL20972712 | 0.76 | KDM4E (0.32) | KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL20745752 | 0.76 | CHRM2 (0.33) | — | |
| SCHEMBL20745753 | 0.76 | CHRM2 (0.33) | — | |
| SCHEMBL20972563 | 0.75 | CHRM2 (0.32) | — | |
| SCHEMBL20972699 | 0.75 | CHRM2 (0.32) | — | |
| SCHEMBL20745519 | 0.75 | CHRM2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3652184-A1 | MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE | AbbVie Inc. (US) | 2020-05-20 | — | — | EP | disclosed |
| WO-2019035911-A1 | MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE | ABBVIE INC. (US) | 2019-02-21 | — | — | WO | disclosed |