Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.64 |
| ▸ | TEK | Q02763 | 12/20 | 0.64 |
| ▸ | LCK | P06239 | 9/20 | 0.63 |
| ▸ | SRC | P12931 | 2/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | HCK | P08631 | 4/20 | 0.45 |
| ▸ | FLT3 | P36888 | 4/20 | 0.45 |
| ▸ | BTK | Q06187 | 2/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6461219 | 0.88 | TEK (0.63) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL2075340 | 0.84 | KDR (0.77) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL2073471 | 0.83 | KDR (0.65) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL2075847 | 0.83 | KDR (0.75) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL2073162 | 0.83 | KDR (0.67) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL2074861 | 0.81 | TEK (0.69) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL2072171 | 0.81 | KDR (0.71) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL2075960 | 0.80 | KDR (0.70) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL2074298 | 0.80 | KDR (0.60) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL2075529 | 0.79 | KDR (1.00) | KDRTEKLCKSRCPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863444-B2 | 4-aminopyrrolopyrimidines as kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-01-04 | — | — | US | disclosed |