SCHEMBL20748848

SCHEMBL20748848

CN1CCn2nc(-c3cc(F)cc(Cl)c3)c(C(N)=O)c2C1

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CSNK1E P49674 19/20 0.58
CSNK1D P48730 16/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20749016 0.88 CSNK1E (0.59) CSNK1ECSNK1D
SCHEMBL16722747 0.86 CSNK1E (0.62) CSNK1ECSNK1D
SCHEMBL20748928 0.85 CSNK1E (0.53) CSNK1ECSNK1D
SCHEMBL21131003 0.84 CSNK1E (0.56) CSNK1ECSNK1D
SCHEMBL20748850 0.83 CSNK1E (0.56) CSNK1ECSNK1D
SCHEMBL21131225 0.83 CSNK1E (0.71) CSNK1ECSNK1D
SCHEMBL16728626 0.82 CSNK1E (0.63) CSNK1ECSNK1D
SCHEMBL20748944 0.82 CSNK1E (0.68) CSNK1ECSNK1D
SCHEMBL18179641 0.82 CSNK1E (0.49) CSNK1ECSNK1D
SCHEMBL16728830 0.81 CSNK1D (0.70) CSNK1ECSNK1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3068784-B1 SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2019-02-20 EP disclosed