Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.30 |
| ▸ | PIM1 | P11309 | 2/20 | 0.30 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28792087 | 0.86 | PLAT (0.35) | TLR9TLR8TLR7HTR2AHTR2C | |
| SCHEMBL20691669 | 0.82 | MAPK1 (0.37) | TLR9TLR8TLR7 | |
| SCHEMBL16722727 | 0.81 | TLR9 (0.38) | TLR9TLR8TLR7HTR2AHTR2C | |
| SCHEMBL21131230 | 0.80 | PDE4D (0.42) | — | |
| SCHEMBL26943913 | 0.74 | PDCD1 (0.35) | HTR2AHTR2C | |
| SCHEMBL16728716 | 0.74 | CSNK1D (0.48) | TLR9TLR8TLR7CSNK1DCSNK1E | |
| SCHEMBL16722719 | 0.74 | TLR9 (0.54) | TLR9TLR8TLR7CSNK1DACVR1 | |
| SCHEMBL16722760 | 0.74 | CSNK1E (0.50) | TLR9TLR8TLR7CSNK1DCSNK1E | |
| SCHEMBL16722416 | 0.73 | TLR9 (0.54) | TLR9TLR8TLR7CSNK1DCSNK1E | |
| SCHEMBL16708792 | 0.73 | CSNK1E (0.54) | TLR9TLR8TLR7CSNK1DTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068784-B1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-02-20 | — | — | EP | disclosed |