Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 14/20 | 0.58 |
| ▸ | CSNK1D | P48730 | 12/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.44 |
| ▸ | BTK | Q06187 | 3/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16700548 | 0.89 | CSNK1E (0.63) | CSNK1ECSNK1DRIPK2BTK | |
| SCHEMBL21131257 | 0.88 | CSNK1E (0.56) | CSNK1ECSNK1DRIPK2BTK | |
| SCHEMBL16711462 | 0.87 | CSNK1E (0.67) | CSNK1ECSNK1D | |
| SCHEMBL16709034 | 0.86 | CSNK1E (0.59) | CSNK1ECSNK1DRIPK2BTK | |
| SCHEMBL18184155 | 0.83 | CSNK1E (0.73) | CSNK1ECSNK1DBTK | |
| SCHEMBL16700696 | 0.83 | CSNK1E (0.52) | CSNK1ECSNK1DRIPK2BTKTGFBR1 | |
| SCHEMBL16699603 | 0.82 | CSNK1E (0.70) | CSNK1ECSNK1DRIPK2BTK | |
| SCHEMBL21131080 | 0.82 | CSNK1E (0.61) | CSNK1ECSNK1D | |
| SCHEMBL16711524 | 0.82 | CSNK1E (0.61) | CSNK1ECSNK1D | |
| SCHEMBL16700159 | 0.82 | CSNK1E (0.61) | CSNK1ECSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068784-B1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-02-20 | — | — | EP | disclosed |