Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 3/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.49 |
| ▸ | SLC34A1 | Q06495 | 2/20 | 0.36 |
| ▸ | CACNB4 | O00305 | 2/20 | 0.36 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.36 |
| ▸ | CACNG3 | O60359 | 2/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.36 |
| ▸ | CACNB3 | P54284 | 2/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.36 |
| ▸ | CACNG7 | P62955 | 2/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.36 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.36 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.36 |
| ▸ | CACNG1 | Q06432 | 2/20 | 0.36 |
| ▸ | CACNB2 | Q08289 | 2/20 | 0.36 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.36 |
| ▸ | CACNA1E | Q15878 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16709084 | 0.90 | CSNK1E (0.51) | CSNK1ECSNK1DCACNB4CACNA1ACACNA1G | |
| SCHEMBL16709083 | 0.86 | CSNK1E (0.65) | CSNK1ECSNK1DBTK | |
| SCHEMBL16711445 | 0.86 | CSNK1E (0.56) | CSNK1ECSNK1DGPR119BTKKCNK3 | |
| SCHEMBL16709082 | 0.81 | CSNK1E (0.43) | CSNK1ECSNK1DCACNB4CACNA1ACACNA1G | |
| SCHEMBL16709077 | 0.80 | CSNK1E (0.67) | CSNK1ECSNK1DBTK | |
| SCHEMBL16709034 | 0.80 | CSNK1E (0.59) | CSNK1ECSNK1DBTK | |
| SCHEMBL16709061 | 0.77 | CSNK1E (0.53) | CSNK1ECSNK1DKAT8BTK | |
| SCHEMBL16728848 | 0.77 | CSNK1E (0.54) | CSNK1ECSNK1DBTK | |
| SCHEMBL16699092 | 0.76 | CSNK1E (0.55) | CSNK1ECSNK1DBTK | |
| SCHEMBL16709031 | 0.76 | CSNK1E (0.55) | CSNK1ECSNK1DBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068785-B1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-06-26 | — | — | EP | disclosed |
| EP-3068784-B1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-02-20 | — | — | EP | disclosed |