Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 3/20 | 0.67 |
| ▸ | SRC | P12931 | 8/20 | 0.54 |
| ▸ | ABL1 | P00519 | 6/20 | 0.54 |
| ▸ | EGFR | P00533 | 6/20 | 0.54 |
| ▸ | ABL2 | P42684 | 6/20 | 0.54 |
| ▸ | EIF2AK3 | Q9NZJ5 | 8/20 | 0.54 |
| ▸ | LCK | P06239 | 3/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | NPM1 | P06748 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | ROS1 | P08922 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12934111 | 0.91 | TEK (0.71) | TEKSRCABL1EGFRABL2 | |
| SCHEMBL12934114 | 0.91 | TEK (0.71) | TEKSRCABL1EGFRABL2 | |
| SCHEMBL12934120 | 0.90 | TEK (0.70) | TEKSRCABL1EGFRABL2 | |
| SCHEMBL2075286 | 0.90 | TEK (0.81) | TEKSRCABL1EGFRABL2 | |
| SCHEMBL7006046 | 0.88 | TEK (0.68) | TEKSRCABL1EGFRABL2 | |
| SCHEMBL2072174 | 0.88 | TEK (0.67) | TEKSRCABL1EGFRABL2 | |
| SCHEMBL12934119 | 0.88 | TEK (0.67) | TEKSRCABL1EGFRABL2 | |
| SCHEMBL12934124 | 0.88 | TEK (0.69) | TEKSRCABL1EGFRABL2 | |
| SCHEMBL2074229 | 0.86 | TEK (0.65) | TEKSRCABL1EGFRABL2 | |
| SCHEMBL12934138 | 0.86 | TEK (0.73) | TEKSRCABL1EGFRABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863444-B2 | 4-aminopyrrolopyrimidines as kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-01-04 | — | — | US | disclosed |
| EP-1114052-B1 | 4-AMINOPYRROLOPYRIMIDINES AS KINASE INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2005-11-16 | — | — | EP | disclosed |
| US-20050008640-A1 | Method of treating transplant rejection | ABBOTT LABORATORIES | 2005-01-13 | — | — | US | disclosed |
| US-20030187001-A1 | 4-AMINOPYRROLOPYRIMIDINES AS KINASE INHIBITORS | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2003-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050008640-A1 | Method of treating transplant rejection | LCK, ZAP70, FYN | TEK 1465/4885SRC 46/4885ABL1 122/4885 |
| US-20030187001-A1 | 4-AMINOPYRROLOPYRIMIDINES AS KINASE INHIBITORS | LCK, PPP5C, DUSP1 | TEK 199/4885SRC 89/4885ABL1 189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.