Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19368254 | 0.90 | NOTUM (0.51) | NOTUMNPC1MAPTRAB9AMAPK1 | |
| SCHEMBL24681187 | 0.84 | NOTUM (0.45) | NOTUMNPC1MAPTMAPK1ALDH1A1 | |
| SCHEMBL19368164 | 0.83 | NOTUM (0.44) | NOTUMMAPK1ALDH1A1KDM4EHPGD | |
| SCHEMBL20756834 | 0.82 | BPTF (0.51) | NOTUMKDM4EHPGDHTT | |
| SCHEMBL20756550 | 0.81 | CHKA (0.52) | MAPK1ALDH1A1TSHRRECQLKMT2A | |
| SCHEMBL24681307 | 0.80 | NOTUM (0.37) | NOTUM | |
| SCHEMBL12988745 | 0.80 | MAPT (0.48) | NOTUMNPC1MAPTRAB9AMAPK1 | |
| SCHEMBL20756890 | 0.79 | HTT (0.46) | MAPTALDH1A1KDM4EHTT | |
| SCHEMBL24844832 | 0.79 | HTT (0.49) | MAPTRAB9AALDH1A1TSHRKDM4E | |
| SCHEMBL15383528 | 0.78 | KDM4E (0.57) | NOTUMNPC1MAPTRAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019036377-A1 | TRICYCLIC COMPOUNDS AS HISTONE METHYL-TRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2019-02-21 | — | — | WO | disclosed |