Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 18/20 | 0.68 |
| ▸ | CDK4 | P11802 | 11/20 | 0.68 |
| ▸ | AURKA | O14965 | 10/20 | 0.68 |
| ▸ | AURKB | Q96GD4 | 9/20 | 0.68 |
| ▸ | CDK9 | P50750 | 10/20 | 0.61 |
| ▸ | CDK1 | P06493 | 7/20 | 0.61 |
| ▸ | CDK7 | P50613 | 6/20 | 0.61 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.58 |
| ▸ | PLK1 | P53350 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 3/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.56 |
| ▸ | JAK1 | P23458 | 2/20 | 0.56 |
| ▸ | JAK3 | P52333 | 2/20 | 0.56 |
| ▸ | CDC7 | O00311 | 1/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | CIT | O14578 | 1/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | GAK | O14976 | 1/20 | 0.56 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2076774 | 0.92 | CDK2 (0.61) | CDK2CDK4AURKAAURKBCDK9 | |
| SCHEMBL4166368 | 0.84 | CDK2 (0.74) | CDK2CDK4AURKAAURKBCDK9 | |
| SCHEMBL2074206 | 0.82 | CDK2 (0.69) | CDK2CDK4AURKAAURKBCDK9 | |
| SCHEMBL2073867 | 0.81 | CDK2 (1.00) | CDK2CDK4AURKAAURKBCDK9 | |
| SCHEMBL2076610 | 0.81 | CDK2 (0.60) | CDK2CDK4AURKAAURKBCDK9 | |
| SCHEMBL4903416 | 0.81 | JAK2 (0.62) | JAK2JAK1JAK3PLK4CIT | |
| SCHEMBL4159243 | 0.81 | CDK2 (0.69) | CDK2CDK4AURKAAURKBCDK9 | |
| SCHEMBL14348363 | 0.80 | JAK2 (0.64) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL4899494 | 0.80 | SYK (0.57) | JAK2JAK1JAK3EGFRTYK2 | |
| SCHEMBL2076084 | 0.80 | CDK2 (0.58) | CDK2CDK4AURKAAURKBCDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1864983-A1 | PYRIMIDINE COMPOUNDS AS CYCLIN-DEPENDENT KINASE INHIBITORS | Cyclacel Limited (GB) | 2007-12-12 | — | — | EP | claimed |
| US-20050192300-A1 | Pyrimidine compounds | CYCLACEL LIMITED (GB) | 2005-09-01 | — | — | US | claimed |
| US-7897605-B2 | Pyrimidine compounds | CYCLACEL LIMITED (GB) | 2011-03-01 | — | — | US | disclosed |
| US-7897605-B2 | Pyrimidine compounds | CYCLACEL LIMITED (GB) | 2011-03-01 | — | — | US | disclosed |
| US-7897605-B2 | Pyrimidine compounds | CYCLACEL LIMITED (GB) | 2011-03-01 | — | — | US | disclosed |
| US-20080287439-A1 | Pyrimidine compounds | CYCLACEL LIMITED (GB) | 2008-11-20 | — | — | US | disclosed |
| US-20080287439-A1 | Pyrimidine compounds | CYCLACEL LIMITED (GB) | 2008-11-20 | — | — | US | disclosed |
| US-20080287439-A1 | Pyrimidine compounds | CYCLACEL LIMITED (GB) | 2008-11-20 | — | — | US | disclosed |
| US-7432260-B2 | Pyrimidine compounds | CYCLACEL LIMTED (GB) | 2008-10-07 | — | — | US | disclosed |
| US-7432260-B2 | Pyrimidine compounds | CYCLACEL LIMTED (GB) | 2008-10-07 | — | — | US | disclosed |
| US-7432260-B2 | Pyrimidine compounds | CYCLACEL LIMTED (GB) | 2008-10-07 | — | — | US | disclosed |
| EP-1864983-A1 | PYRIMIDINE COMPOUNDS AS CYCLIN-DEPENDENT KINASE INHIBITORS | Cyclacel Limited (GB) | 2007-12-12 | — | — | EP | disclosed |
| EP-1864983-A1 | PYRIMIDINE COMPOUNDS AS CYCLIN-DEPENDENT KINASE INHIBITORS | Cyclacel Limited (GB) | 2007-12-12 | — | — | EP | disclosed |
| US-20050192300-A1 | Pyrimidine compounds | CYCLACEL LIMITED (GB) | 2005-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287439-A1 | Pyrimidine compounds | CDK2, CCNI, CDK6 | CDK2 1/4885CDK4 7/4885AURKA 123/4885 |
| US-20050192300-A1 | Pyrimidine compounds | CDK2, CCNI, CDK6 | CDK2 1/4885CDK4 7/4885AURKA 123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.