Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK7 | Q8TDX7 | 5/20 | 0.52 |
| ▸ | EGFR | P00533 | 8/20 | 0.52 |
| ▸ | TEK | Q02763 | 4/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.52 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.52 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.52 |
| ▸ | ABL1 | P00519 | 5/20 | 0.51 |
| ▸ | SRC | P12931 | 5/20 | 0.51 |
| ▸ | ABL2 | P42684 | 5/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | INSR | P06213 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | NPM1 | P06748 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | ROS1 | P08922 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2071940 | 0.95 | EGFR (0.55) | NEK7EGFRTEKERBB2ERBB3 | |
| SCHEMBL6460003 | 0.91 | TEK (0.63) | NEK7EGFRTEKERBB2ERBB3 | |
| SCHEMBL2074616 | 0.89 | EIF2AK3 (0.54) | NEK7EGFRTEKERBB2ERBB3 | |
| SCHEMBL2075923 | 0.89 | EGFR (0.63) | NEK7EGFRTEKERBB2ERBB3 | |
| SCHEMBL2074937 | 0.88 | RIPK2 (0.53) | NEK7EGFRTEKERBB2ERBB3 | |
| SCHEMBL2074338 | 0.88 | EIF2AK3 (0.53) | NEK7EGFRTEKERBB2ERBB3 | |
| SCHEMBL2074412 | 0.88 | EGFR (0.54) | NEK7EGFRTEKABL1SRC | |
| SCHEMBL12934154 | 0.87 | NEK7 (0.52) | NEK7EGFRTEKERBB2ERBB3 | |
| SCHEMBL6465261 | 0.86 | TEK (0.66) | NEK7EGFRTEKERBB2ERBB3 | |
| SCHEMBL12934104 | 0.85 | EIF2AK3 (0.54) | NEK7EGFRTEKABL1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1114052-B1 | 4-AMINOPYRROLOPYRIMIDINES AS KINASE INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2005-11-16 | — | — | EP | claimed |
| US-20030187001-A1 | 4-AMINOPYRROLOPYRIMIDINES AS KINASE INHIBITORS | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2003-10-02 | — | — | US | claimed |
| US-7863444-B2 | 4-aminopyrrolopyrimidines as kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-01-04 | — | — | US | disclosed |
| US-20050008640-A1 | Method of treating transplant rejection | ABBOTT LABORATORIES | 2005-01-13 | — | — | US | disclosed |
| US-20030187001-A1 | 4-AMINOPYRROLOPYRIMIDINES AS KINASE INHIBITORS | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2003-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050008640-A1 | Method of treating transplant rejection | LCK, ZAP70, FYN | NEK7 3001/4885EGFR 818/4885TEK 1465/4885 |
| US-20030187001-A1 | 4-AMINOPYRROLOPYRIMIDINES AS KINASE INHIBITORS | LCK, PPP5C, DUSP1 | NEK7 2079/4885EGFR 294/4885TEK 199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.