Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.49 |
| ▸ | NRP1 | O14786 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12956699 | 0.80 | KDM4E (0.55) | ACHEKDM4EBRD4HSD17B10GLA | |
| SCHEMBL2073449 | 0.80 | KDM4E (0.49) | ACHEKDM4ENRP1KMT2ARXFP1 | |
| SCHEMBL25057053 | 0.79 | KDM4E (0.54) | ACHEKDM4ENRP1HSD17B10MAPT | |
| SCHEMBL27393494 | 0.77 | KDM4E (0.57) | ACHEKDM4EKMT2AHSD17B10MEN1 | |
| SCHEMBL5783945 | 0.77 | KDM4E (0.51) | ACHEKDM4ENRP1KMT2ARXFP1 | |
| SCHEMBL6885736 | 0.73 | KDM4E (0.43) | ACHEKDM4E | |
| SCHEMBL6017719 | 0.71 | KDM4E (0.50) | ACHEKDM4EKMT2AHSD17B10MEN1 | |
| SCHEMBL2074950 | 0.70 | KDM4E (0.51) | ACHEKDM4ENRP1KMT2AMEN1 | |
| SCHEMBL2074328 | 0.70 | QPCT (0.64) | KDM4EHSD17B10GLALMNATSHR | |
| SCHEMBL22904299 | 0.70 | KDM4E (0.61) | ACHEKDM4EHSD17B10LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863444-B2 | 4-aminopyrrolopyrimidines as kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-01-04 | — | — | US | disclosed |