Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 5/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20764981 | 0.94 | PLAU (0.41) | PLAUBTKLCKLRRK2AAK1 | |
| SCHEMBL20795058 | 0.85 | PLAU (0.41) | PLAUBTKLRRK2AAK1LOXL2 | |
| SCHEMBL30609169 | 0.84 | PLAU (0.45) | PLAUBTKLCKLRRK2AAK1 | |
| SCHEMBL20765130 | 0.84 | PLAU (0.45) | PLAUBTKLCKLRRK2AAK1 | |
| SCHEMBL20765056 | 0.78 | USP30 (0.38) | LRRK2AAK1 | |
| SCHEMBL20764980 | 0.78 | BTK (0.44) | PLAUBTKLCKAAK1LOXL2 | |
| SCHEMBL20765684 | 0.75 | PIK3CD (0.38) | LRRK2PIK3CDPIK3CAPIK3CGTTK | |
| SCHEMBL22183206 | 0.75 | ERN1 (0.38) | PLAULRRK2AAK1LOXL2TTK | |
| SCHEMBL20765041 | 0.74 | FGFR1 (0.41) | FGFR1FGFR2 | |
| SCHEMBL29889203 | 0.74 | FGFR1 (0.41) | FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3672952-A1 | BEZIMIDAZOLE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS | Merck Patent GmbH (DE) | 2020-07-01 | — | — | EP | disclosed |
| WO-2019038215-A1 | BEZIMIDAZOLE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2019-02-28 | — | — | WO | disclosed |