Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 20/20 | 0.70 |
| ▸ | HTR2C | P28335 | 5/20 | 0.70 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.70 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.70 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.70 |
| ▸ | DRD1 | P21728 | 1/20 | 0.70 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.70 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.70 |
| ▸ | GPR183 | P32249 | 1/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.70 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.70 |
| ▸ | APLNR | P35414 | 1/20 | 0.70 |
| ▸ | DRD3 | P35462 | 1/20 | 0.70 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.70 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.70 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23686966 | 1.00 | HTR2A (0.70) | HTR2AHTR2CABCB11CYP1A2ADRB2 | |
| SCHEMBL20774949 | 1.00 | HTR2A (0.70) | HTR2AHTR2CABCB11CYP1A2ADRB2 | |
| SCHEMBL29073209 | 0.96 | HTR2A (0.67) | HTR2AHTR2CABCB11CYP1A2ADRB2 | |
| SCHEMBL29072941 | 0.96 | HTR2A (0.67) | HTR2AHTR2CABCB11CYP1A2ADRB2 | |
| SCHEMBL29072944 | 0.96 | HTR2A (0.67) | HTR2AHTR2CABCB11CYP1A2ADRB2 | |
| SCHEMBL23686881 | 0.95 | HTR2A (0.74) | HTR2AHTR2CABCB11CYP1A2ADRB2 | |
| SCHEMBL23686868 | 0.94 | HTR2A (0.66) | HTR2AHTR2CABCB11CYP1A2ADRB2 | |
| SCHEMBL28895880 | 0.92 | HTR2A (0.60) | HTR2AHTR2CABCB11CYP1A2ADRB2 | |
| SCHEMBL28271155 | 0.92 | HTR2A (0.59) | HTR2AHTR2CABCB11CYP1A2ADRB2 | |
| SCHEMBL28272712 | 0.92 | HTR2A (0.59) | HTR2AHTR2CABCB11CYP1A2ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113214289-A | 5-HT2A receptor antagonists and their use for the treatment of central nervous system disorders | 瀚远医药有限公司 | 2021-08-06 | — | — | CN | claimed |
| CN-115677723-B | 5-HT2A receptor antagonists and their use for treating central nervous system disorders | 瀚远医药有限公司 | 2024-06-04 | — | — | CN | disclosed |
| CN-109111385-B | 5-HT 2A Receptor inhibitor and preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2023-06-30 | — | — | CN | disclosed |
| CN-115677723-A | 5-HT2A receptor antagonists and their use for the treatment of central nervous system disorders | 瀚远医药有限公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-113214289-B | 5-HT2A receptor antagonists and their use for the treatment of central nervous system disorders | 瀚远医药有限公司 | 2022-10-28 | — | — | CN | disclosed |
| CN-113214289-A | 5-HT2A receptor antagonists and their use for the treatment of central nervous system disorders | 瀚远医药有限公司 | 2021-08-06 | — | — | CN | disclosed |
| WO-2021147818-A1 | 5-HT2A RECEPTOR ANTAGONIST AND APPLICATION THEREOF IN TREATING CENTRAL NERVOUS SYSTEM DISEASES | 瀚远医药有限公司 | 2021-07-29 | — | — | WO | disclosed |
| WO-2019040106-A2 | COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES | ACADIA PHARMACEUTICALS INC. (US) | 2019-02-28 | — | — | WO | disclosed |