Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.43 |
| ▸ | LMNA | P02545 | 7/20 | 0.43 |
| ▸ | HTT | P42858 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13197078 | 0.82 | MAPK1 (0.53) | MAPK1KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL13202074 | 0.76 | MAPK1 (0.59) | MAPK1KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL21145592 | 0.72 | MAPK1 (0.55) | MAPK1KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL17493910 | 0.71 | MAPK1 (0.59) | MAPK1KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL13325616 | 0.71 | MAPK1 (0.53) | MAPK1KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL11438926 | 0.71 | HSD17B10 (0.54) | MAPK1KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL19182209 | 0.71 | HSD17B10 (0.54) | MAPK1KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL11437970 | 0.71 | HSD17B10 (0.54) | MAPK1KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL6912162 | 0.71 | HSD17B10 (0.54) | MAPK1KDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL9027068 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE47415-E1 | Pyrimidinecarboxamides as CXCR2 modulators | SYNTRIX BIOSYSTEMS, INC. (US) | 2019-06-04 | — | — | US | disclosed |
| US-RE47267-E1 | Pyridinecarboxamides as CXCR2 modulators | SYNTRIX BIOSYSTEMS, INC. (US) | 2019-03-05 | — | — | US | disclosed |