Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 4/20 | 0.32 |
| ▸ | PRKDC | P78527 | 2/20 | 0.32 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.32 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL262307 | 0.80 | GRM5 (0.54) | GRM5PRKCIATRACVR2ATGFBR2 | |
| SCHEMBL20781131 | 0.79 | GRM5 (0.31) | GRM5 | |
| SCHEMBL18793259 | 0.77 | GRM5 (0.46) | GRM5MAPKAPK2PRKCIATRPRKDC | |
| SCHEMBL18502144 | 0.73 | GRM5 (0.46) | GRM5MAPKAPK2PRKCIACVR2ATGFBR2 | |
| SCHEMBL20780881 | 0.73 | GRM5 (0.46) | GRM5LMNANOS3NOS2 | |
| SCHEMBL18502145 | 0.72 | GRM5 (0.53) | GRM5MAPKAPK2PRKCILMNAATR | |
| SCHEMBL3575758 | 0.72 | GRM5 (0.53) | GRM5MAPKAPK2PRKCIATRPRKDC | |
| SCHEMBL14525247 | 0.72 | GRM5 (0.53) | GRM5MAPKAPK2PRKCIATRPRKDC | |
| SCHEMBL17635824 | 0.71 | GRM5 (0.60) | GRM5MAPKAPK2PRKCIATRPRKDC | |
| SCHEMBL13138607 | 0.71 | GRM5 (0.60) | GRM5PRKCIATRPRKDCACVR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019043407-A1 | SUBSTITUTED 2-AZABICYCLO[3.1.1]HEPTANE AND 2-AZABICYCLO[3.2.1]OCTANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | CHRONOS THERAPEUTICS LIMITED (GB) | 2019-03-07 | — | — | WO | disclosed |