Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23252609 | 0.89 | DDR1 (0.50) | DDR1 | |
| SCHEMBL29444536 | 0.89 | DDR1 (0.62) | DDR1DDR2 | |
| SCHEMBL19235156 | 0.89 | DDR1 (0.62) | DDR1DDR2 | |
| SCHEMBL19211044 | 0.89 | DDR1 (0.61) | DDR1DDR2 | |
| SCHEMBL19235203 | 0.89 | DDR1 (0.60) | DDR1DDR2 | |
| SCHEMBL19235275 | 0.88 | DDR1 (0.61) | DDR1DDR2 | |
| SCHEMBL20783419 | 0.88 | DDR1 (0.61) | DDR1DDR2 | |
| SCHEMBL19235380 | 0.88 | DDR1 (0.61) | DDR1DDR2 | |
| SCHEMBL20783557 | 0.87 | DDR1 (0.64) | DDR1DDR2 | |
| SCHEMBL19235157 | 0.86 | DDR1 (0.63) | DDR1DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414247-B1 | SPIROINDOLINONES AS DDR1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-04-21 | — | — | EP | disclosed |
| EP-3414247-B1 | SPIROINDOLINONES AS DDR1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-04-21 | — | — | EP | disclosed |
| US-20190071444-A1 | SPIROINDOLINONES AS DDR1 INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2019-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190071444-A1 | SPIROINDOLINONES AS DDR1 INHIBITORS | DDR1, DDR2, DDRGK1 | DDR1 1/4885DDR2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.