SCHEMBL20787141

SCHEMBL20787141

C[SH]1C[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]1c1ccc(Cl)c(Cc2ccc(OCCNC(=O)O)cc2)c1

nearest known ligand 0.50

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC5A1 P13866 14/20 0.50
SLC5A2 P31639 11/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20787161 0.91 SLC5A1 (0.49) SLC5A1SLC5A2
SCHEMBL20787315 0.89 SLC5A1 (0.46) SLC5A1SLC5A2
SCHEMBL20787359 0.88 SLC5A1 (0.60) SLC5A1SLC5A2
SCHEMBL20787305 0.88 SLC5A1 (0.59) SLC5A1SLC5A2
SCHEMBL20787121 0.87 SLC5A1 (0.65) SLC5A1SLC5A2
SCHEMBL20787209 0.87 SLC5A1 (0.53) SLC5A1SLC5A2
SCHEMBL20787207 0.86 SLC5A2 (0.57) SLC5A1SLC5A2
SCHEMBL20787220 0.86 SLC5A1 (0.44) SLC5A1SLC5A2
SCHEMBL20787137 0.86 SLC5A1 (0.49) SLC5A1SLC5A2
SCHEMBL20787165 0.85 SLC5A1 (0.56) SLC5A1SLC5A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3489226-B1 INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1 LEXICON PHARMACEUTICALS INC (US) 2021-02-17 EP disclosed
EP-2925735-B1 INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1 LEXICON PHARMACEUTICALS INC (US) 2019-03-13 EP disclosed