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SCHEMBL20787142

SCHEMBL20787142

CS[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(OCC(=O)NC(C)(C)C(N)=O)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ SLC5A1 P13866 20/20 1.00
▸ SLC5A2 P31639 7/20 0.84

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20787202 0.92 SLC5A1 (0.84) SLC5A1SLC5A2
SCHEMBL15748723 0.91 SLC5A1 (1.00) SLC5A1SLC5A2
SCHEMBL20787351 0.89 SLC5A1 (1.00) SLC5A1SLC5A2
SCHEMBL20787219 0.88 SLC5A1 (0.78) SLC5A1SLC5A2
SCHEMBL20787405 0.87 SLC5A1 (1.00) SLC5A1SLC5A2
SCHEMBL20787206 0.85 SLC5A1 (1.00) SLC5A1SLC5A2
SCHEMBL18212628 0.84 SLC5A1 (0.83) SLC5A1SLC5A2
SCHEMBL16169587 0.83 SLC5A1 (0.85) SLC5A1SLC5A2
SCHEMBL20787193 0.82 SLC5A1 (1.00) SLC5A1SLC5A2
SCHEMBL15748747 0.81 SLC5A1 (1.00) SLC5A1SLC5A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3489226-B1 INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1 LEXICON PHARMACEUTICALS INC (US) 2021-02-17 — — EP disclosed
EP-3489226-A1 INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1 Lexicon Pharmaceuticals, Inc. (US) 2019-05-29 — — EP disclosed
EP-2925735-B1 INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1 LEXICON PHARMACEUTICALS INC (US) 2019-03-13 — — EP disclosed