SCHEMBL20787152

SCHEMBL20787152

CCOc1ccc(Cc2cc([C@H]3[C@H](O)[C@H](O)[C@H](O)C[SH]3C)ccc2C)cc1

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 18/20 0.56
SLC5A1 P13866 13/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19512360 0.88 SLC5A2 (0.58) SLC5A2SLC5A1
SCHEMBL19512412 0.88 SLC5A2 (0.58) SLC5A2SLC5A1
SCHEMBL20787284 0.88 SLC5A2 (0.56) SLC5A2SLC5A1
SCHEMBL20787318 0.87 SLC5A1 (0.58) SLC5A2SLC5A1
SCHEMBL20787126 0.87 SLC5A1 (0.57) SLC5A2SLC5A1
SCHEMBL26185382 0.86 SLC5A2 (0.52) SLC5A2SLC5A1
SCHEMBL20787288 0.86 SLC5A1 (0.46) SLC5A2SLC5A1
SCHEMBL20787175 0.85 SLC5A1 (0.58) SLC5A2SLC5A1
SCHEMBL20480708 0.85 SLC5A2 (0.58) SLC5A2SLC5A1
SCHEMBL20787140 0.84 SLC5A1 (0.50) SLC5A2SLC5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3489226-B1 INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1 LEXICON PHARMACEUTICALS INC (US) 2021-02-17 EP disclosed
EP-3489226-A1 INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1 Lexicon Pharmaceuticals, Inc. (US) 2019-05-29 EP disclosed
EP-2925735-B1 INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1 LEXICON PHARMACEUTICALS INC (US) 2019-03-13 EP disclosed