Sugi Predict

Sugi Predict / Compounds / SCHEMBL20787290

SCHEMBL20787290

SCHEMBL20787290

CS[C@H]1O[C@@H](c2ccc(C)c(Cc3ccc(OCCCC(=O)NC(C)(C)C(=O)NCCN(C)C)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O

nearest known ligand 0.84

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ SLC5A1 P13866 18/20 0.84
▸ SLC5A2 P31639 10/20 0.84

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26806177 0.92 SLC5A1 (0.72) SLC5A1SLC5A2
SCHEMBL29474368 0.92 SLC5A1 (1.00) SLC5A1SLC5A2
SCHEMBL15741132 0.92 SLC5A1 (1.00) SLC5A1SLC5A2
SCHEMBL21028738 0.92 SLC5A1 (1.00) SLC5A1SLC5A2
SCHEMBL20787158 0.90 SLC5A1 (1.00) SLC5A1SLC5A2
SCHEMBL26806197 0.90 SLC5A1 (0.70) SLC5A1SLC5A2
SCHEMBL24029979 0.88 SLC5A1 (0.68) SLC5A1SLC5A2
SCHEMBL20787103 0.88 SLC5A1 (0.82) SLC5A1SLC5A2
SCHEMBL16169587 0.87 SLC5A1 (0.85) SLC5A1SLC5A2
SCHEMBL24029638 0.85 SLC5A1 (0.88) SLC5A1SLC5A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3489226-B1 INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1 LEXICON PHARMACEUTICALS INC (US) 2021-02-17 — — EP disclosed
EP-3489226-A1 INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1 Lexicon Pharmaceuticals, Inc. (US) 2019-05-29 — — EP disclosed
EP-2925735-B1 INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1 LEXICON PHARMACEUTICALS INC (US) 2019-03-13 — — EP disclosed