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SCHEMBL20787372

SCHEMBL20787372

CS[C@H]1O[C@@H](c2ccc(C)c(Cc3ccc(CCCC(=O)NCC(C)(C)C(=O)N(C)CCN(C)C)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ SLC5A2 P31639 9/20 1.00
▸ SLC5A1 P13866 18/20 0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20787146 0.91 SLC5A1 (1.00) SLC5A2SLC5A1
SCHEMBL20787293 0.88 SLC5A1 (1.00) SLC5A2SLC5A1
SCHEMBL20787327 0.86 SLC5A1 (0.84) SLC5A2SLC5A1
SCHEMBL15748745 0.83 SLC5A1 (0.85) SLC5A2SLC5A1
SCHEMBL15741132 0.83 SLC5A1 (1.00) SLC5A2SLC5A1
SCHEMBL29474368 0.83 SLC5A1 (1.00) SLC5A2SLC5A1
SCHEMBL21028738 0.83 SLC5A1 (1.00) SLC5A2SLC5A1
SCHEMBL27272156 0.83 SLC5A1 (0.84) SLC5A2SLC5A1
SCHEMBL20787239 0.83 SLC5A1 (1.00) SLC5A2SLC5A1
SCHEMBL20787158 0.82 SLC5A1 (1.00) SLC5A2SLC5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3489226-B1 INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1 LEXICON PHARMACEUTICALS INC (US) 2021-02-17 — — EP disclosed
EP-3489226-A1 INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1 Lexicon Pharmaceuticals, Inc. (US) 2019-05-29 — — EP disclosed
EP-2925735-B1 INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1 LEXICON PHARMACEUTICALS INC (US) 2019-03-13 — — EP disclosed