Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 16/20 | 0.80 |
| ▸ | PIM1 | P11309 | 4/20 | 0.68 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.68 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2077745 | 0.90 | CHEK1 (0.78) | CHEK1 | |
| SCHEMBL2077240 | 0.89 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL2080019 | 0.88 | CHEK1 (0.76) | CHEK1 | |
| SCHEMBL2080016 | 0.88 | CHEK1 (0.76) | CHEK1 | |
| SCHEMBL2077396 | 0.87 | CHEK1 (0.74) | CHEK1PIM1PIM3PIM2 | |
| SCHEMBL2079970 | 0.87 | CHEK1 (0.74) | CHEK1PIM1PIM3 | |
| SCHEMBL14328518 | 0.87 | CHEK1 (0.96) | CHEK1 | |
| SCHEMBL2079013 | 0.87 | CHEK1 (0.74) | CHEK1 | |
| SCHEMBL15071640 | 0.87 | CHEK1 (0.84) | CHEK1PIM1PIM3 | |
| SCHEMBL14207142 | 0.86 | CHEK1 (0.81) | CHEK1PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163746-B2 | Azolecarboxamide derivative | ASTELLAS PHARMA INC. (JP) | 2012-04-24 | — | — | US | disclosed |
| US-20090286766-A1 | AZOLECARBOXAMIDE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2009-11-19 | — | — | US | disclosed |
| EP-2009005-A1 | AZOLECARBOXAMIDE DERIVATIVE | Astellas Pharma Inc. (JP) | 2008-12-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286766-A1 | AZOLECARBOXAMIDE DERIVATIVE | GPR17, NTRK1, TRPV1 | CHEK1 2676/4885PIM1 830/4885PIM3 773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.