Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.48 |
| ▸ | HTR2C | P28335 | 4/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | GPR183 | P32249 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | APLNR | P35414 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20794534 | 1.00 | HTR2A (0.48) | HTR2AHTR2CHRH3ABCB11CYP1A2 | |
| SCHEMBL20794669 | 1.00 | HTR2A (0.48) | HTR2AHTR2CHRH3ABCB11CYP1A2 | |
| SCHEMBL20765893 | 0.89 | HTR2A (0.61) | HTR2AHTR2CHRH3ABCB11CYP1A2 | |
| SCHEMBL20794652 | 0.88 | HTR2A (0.64) | HTR2AHTR2CHRH3ABCB11CYP1A2 | |
| SCHEMBL20794645 | 0.88 | HTR2A (0.64) | HTR2AHTR2CHRH3ABCB11CYP1A2 | |
| SCHEMBL20794651 | 0.88 | HTR2A (0.64) | HTR2AHTR2CHRH3ABCB11CYP1A2 | |
| SCHEMBL20794958 | 0.83 | HTR2A (0.49) | HTR2AHTR2CHRH3ABCB11CYP1A2 | |
| SCHEMBL20794633 | 0.82 | HTR2A (0.71) | HTR2AHTR2CHRH3ABCB11CYP1A2 | |
| SCHEMBL20766115 | 0.81 | HTR2A (0.51) | HTR2AOPRM1 | |
| SCHEMBL20794846 | 0.81 | HTR2A (0.51) | HTR2AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019040106-A2 | COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES | ACADIA PHARMACEUTICALS INC. (US) | 2019-02-28 | — | — | WO | disclosed |