Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12775391 | 1.00 | MEN1 (0.60) | MEN1KMT2APOLBALDH1A1RAB9A | |
| SCHEMBL2079598 | 1.00 | MEN1 (0.60) | MEN1KMT2APOLBALDH1A1RAB9A | |
| SCHEMBL2340642 | 0.81 | KMT2A (0.53) | MEN1KMT2APOLBALDH1A1RAB9A | |
| SCHEMBL2340650 | 0.81 | KMT2A (0.53) | MEN1KMT2APOLBALDH1A1RAB9A | |
| SCHEMBL2333590 | 0.80 | MEN1 (0.54) | MEN1KMT2APOLBALDH1A1RAB9A | |
| SCHEMBL2333596 | 0.80 | MEN1 (0.54) | MEN1KMT2APOLBALDH1A1RAB9A | |
| SCHEMBL2080440 | 0.80 | MEN1 (0.58) | MEN1KMT2APOLBALDH1A1RAB9A | |
| SCHEMBL2080442 | 0.80 | MEN1 (0.58) | MEN1KMT2APOLBALDH1A1RAB9A | |
| SCHEMBL2340400 | 0.78 | MAPT (0.58) | MEN1KMT2APOLBALDH1A1LMNA | |
| SCHEMBL2340397 | 0.78 | MAPT (0.58) | MEN1KMT2APOLBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902237-B2 | nuclear receptor activity modulators; 4-(ethylamino)-3-{[(2Z,5Z)-5-{[methyl(phenyl)amino]methylidene}-4-oxo-3-(phenylmethyl)-1,3-thiazolidin-2-ylidene]amino}benzonitrile; diseases or disorders affected by abnormal cholesterol, triglyceride, or bile acid levels | EXELIXIS, INC. (US) | 2011-03-08 | — | — | US | disclosed |
| US-20080132519-A1 | Heterocyclic Compounds As Pharmaceutical Agents | EXELIXIS, INC. (US) | 2008-06-05 | — | — | US | disclosed |
| EP-1776112-A2 | HETEROCYCLIC COMPOUNDS AS PHARMACEUTICAL AGENTS | Exelixis, Inc. (US) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006020680-A2 | HETEROCYCLIC COMPOUNDS AS PHARMACEUTICAL AGENTS | EXELIXIS, INC. (US) | 2006-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132519-A1 | Heterocyclic Compounds As Pharmaceutical Agents | CNR1, CNR2, TACR2 | MEN1 2621/4885KMT2A 4438/4885POLB 4298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.