Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20797675 | 0.91 | KAT2B (0.44) | KAT2BMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL17819071 | 0.82 | KAT2B (0.52) | KAT2BMAPTSMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL20797644 | 0.82 | KAT2B (0.39) | KAT2BMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL20797603 | 0.82 | KAT2B (0.43) | KAT2BMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL20797762 | 0.82 | KAT2B (0.46) | KAT2BMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL18322365 | 0.80 | KAT2B (0.44) | KAT2BMAPTTDP1L3MBTL1MAPK1 | |
| SCHEMBL15423129 | 0.80 | MAPT (0.43) | MAPTSMN1; SMN2NPC1RAB9AALPG | |
| SCHEMBL10480286 | 0.77 | KAT2B (0.46) | KAT2BMAPTNPC1RAB9ATDP1 | |
| SCHEMBL20810984 | 0.77 | KAT2B (0.39) | KAT2BMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL20797741 | 0.76 | KDM4E (0.39) | MAPTSMN1; SMN2NPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019049061-A1 | 5-(1 H-BENZO[D]IMIDAZO-2-YL)-PYRIDIN-2-AMINE AND 5-(3H-IMIDAZO[4,5-B]PYRIDIN-6-YL)-PYRIDIN-2-AMINE DERIVATIVES AS C-MYC AND P300/CBP HISTONE ACETYLTRANSFERASE INHIBITORS FOR TREATING CANCER | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-03-14 | — | — | WO | disclosed |