Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 1/20 | 0.42 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 8/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | KLK1 | P06870 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | EED | O75530 | 1/20 | 0.36 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.36 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20797592 | 1.00 | KCNJ1 (0.42) | KCNJ1SMPD3CHRM4JAK3KLKB1 | |
| SCHEMBL20810990 | 0.91 | KCNJ1 (0.44) | KCNJ1CHRM4FFAR1 | |
| SCHEMBL30249570 | 0.79 | MTOR (0.43) | — | |
| SCHEMBL20810821 | 0.79 | KCNJ1 (0.40) | KCNJ1FFAR1PDE10A | |
| SCHEMBL25082252 | 0.79 | MTOR (0.43) | — | |
| SCHEMBL25359631 | 0.79 | MTOR (0.43) | — | |
| SCHEMBL20810820 | 0.79 | KCNJ1 (0.40) | KCNJ1FFAR1PDE10A | |
| SCHEMBL31463476 | 0.79 | MTOR (0.43) | — | |
| SCHEMBL20797535 | 0.78 | KCNJ1 (0.46) | KCNJ1 | |
| SCHEMBL20797345 | 0.78 | KCNJ1 (0.46) | KCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019049061-A1 | 5-(1 H-BENZO[D]IMIDAZO-2-YL)-PYRIDIN-2-AMINE AND 5-(3H-IMIDAZO[4,5-B]PYRIDIN-6-YL)-PYRIDIN-2-AMINE DERIVATIVES AS C-MYC AND P300/CBP HISTONE ACETYLTRANSFERASE INHIBITORS FOR TREATING CANCER | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-03-14 | — | — | WO | disclosed |
| WO-2019049061-A1 | 5-(1 H-BENZO[D]IMIDAZO-2-YL)-PYRIDIN-2-AMINE AND 5-(3H-IMIDAZO[4,5-B]PYRIDIN-6-YL)-PYRIDIN-2-AMINE DERIVATIVES AS C-MYC AND P300/CBP HISTONE ACETYLTRANSFERASE INHIBITORS FOR TREATING CANCER | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-03-14 | — | — | WO | disclosed |