Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24244003 | 1.00 | GRM4 (1.00) | GRM4 | |
| SCHEMBL20160433 | 1.00 | GRM4 (1.00) | GRM4 | |
| SCHEMBL24244008 | 0.95 | GRM4 (1.00) | GRM4 | |
| SCHEMBL24244006 | 0.94 | GRM4 (1.00) | GRM4 | |
| SCHEMBL24244045 | 0.89 | GRM4 (0.80) | GRM4 | |
| SCHEMBL19794742 | 0.88 | GRM4 (1.00) | GRM4 | |
| SCHEMBL20160386 | 0.88 | GRM4 (0.78) | GRM4 | |
| SCHEMBL20141380 | 0.88 | GRM4 (0.78) | GRM4 | |
| SCHEMBL20141377 | 0.88 | GRM4 (0.78) | GRM4 | |
| SCHEMBL19794612 | 0.88 | GRM4 (0.78) | GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10227343-B2 | Isoquiniline and napthalene-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction | VANDERBILT UNIVERSITY (US) | 2019-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10227343-B2 | Isoquiniline and napthalene-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction | GRIA4, GRM4, GRIK4 | GRM4 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.