SCHEMBL20800137

SCHEMBL20800137

CC[C@H](C)C([C@@H](CC(=O)N1CCC[C@H]1C(OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C)C(C)C

nearest known ligand 0.55

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SSTR2 P30874 2/20 0.46
CYP3A4 P08684 1/20 0.42
FOLH1 Q04609 3/20 0.42
TTR P02766 2/20 0.37
KCNK3 O14649 1/20 0.32
CTSD P07339 6/20 0.31
CTSE P14091 6/20 0.31
BACE1 P56817 4/20 0.31
MMP9 P14780 1/20 0.31
XIAP P98170 1/20 0.31
MLX Q9UH92 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16580104 1.00 SSTR2 (0.46) SSTR2CYP3A4FOLH1TTRKCNK3
SCHEMBL24047111 1.00 SSTR2 (0.46) SSTR2CYP3A4FOLH1TTRKCNK3
SCHEMBL9892963 1.00 SSTR2 (0.46) SSTR2CYP3A4FOLH1TTRKCNK3
SCHEMBL25295471 1.00 SSTR2 (0.46) SSTR2CYP3A4FOLH1TTRKCNK3
SCHEMBL24036409 1.00 SSTR2 (0.46) SSTR2CYP3A4FOLH1TTRKCNK3
SCHEMBL23900253 1.00 SSTR2 (0.46) SSTR2CYP3A4FOLH1TTRKCNK3
SCHEMBL24092997 1.00 SSTR2 (0.46) SSTR2CYP3A4FOLH1TTRKCNK3
SCHEMBL24047110 1.00 SSTR2 (0.46) SSTR2CYP3A4FOLH1TTRKCNK3
SCHEMBL22661595 1.00 SSTR2 (0.46) SSTR2CYP3A4FOLH1TTRKCNK3
SCHEMBL19387543 1.00 SSTR2 (0.46) SSTR2CYP3A4FOLH1TTRKCNK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11903948-B2 Anti-ErbB2 antibody-drug conjugate and composition thereof, preparation method therefor, and use thereof SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) 2024-02-20 US disclosed
US-20230293536-A1 ANTI-ERBB2 ANTIBODY-DRUG CONJUGATE AND COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) 2023-09-21 US disclosed
US-20220008553-A1 ANTI-ERBB2 ANTIBODY-DRUG CONJUGATE AND COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND USE THEREOF SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) 2022-01-13 US disclosed
US-20210252006-A1 ANTI-ERBB2 ANTIBODY-DRUG CONJUGATE AND COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND USE THEREOF SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) 2021-08-19 US disclosed
US-20190076438-A1 ANTI-ERBB2 ANTIBODY-DRUG CONJUGATE AND COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) 2019-03-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190076438-A1 ANTI-ERBB2 ANTIBODY-DRUG CONJUGATE AND COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF ERBB2, ERBB3, EGFR SSTR2 1906/4885CYP3A4 1508/4885FOLH1 164/4885
US-20230293536-A1 ANTI-ERBB2 ANTIBODY-DRUG CONJUGATE AND COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF ERBB2, ERBB3, EGFR SSTR2 1866/4885CYP3A4 1545/4885FOLH1 168/4885
US-11903948-B2 Anti-ErbB2 antibody-drug conjugate and composition thereof, preparation method therefor, and use thereof ERBB2, EGFR, ERBB3 SSTR2 1139/4885CYP3A4 2599/4885FOLH1 801/4885
US-20210252006-A1 ANTI-ERBB2 ANTIBODY-DRUG CONJUGATE AND COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND USE THEREOF ERBB2, EGFR, ERBB3 SSTR2 1139/4885CYP3A4 2599/4885FOLH1 801/4885
US-20220008553-A1 ANTI-ERBB2 ANTIBODY-DRUG CONJUGATE AND COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND USE THEREOF ERBB2, EGFR, ERBB3 SSTR2 1359/4885CYP3A4 3210/4885FOLH1 233/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.