Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 20/20 | 0.80 |
| ▸ | KDR | P35968 | 20/20 | 0.80 |
| ▸ | FGFR1 | P11362 | 19/20 | 0.80 |
| ▸ | FGFR2 | P21802 | 19/20 | 0.80 |
| ▸ | FGFR4 | P22455 | 19/20 | 0.80 |
| ▸ | FLT3 | P36888 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20808264 | 0.92 | FGFR3 (0.84) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL14905218 | 0.89 | FGFR1 (1.00) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL14905577 | 0.89 | FGFR4 (0.82) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL14905531 | 0.89 | FGFR4 (1.00) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL14905567 | 0.88 | FGFR3 (1.00) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL14905407 | 0.88 | FGFR1 (1.00) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL14905520 | 0.86 | FGFR1 (0.79) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL14905516 | 0.85 | FGFR1 (1.00) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL18346569 | 0.85 | FGFR1 (0.77) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL18769091 | 0.85 | FGFR1 (0.77) | FGFR3KDRFGFR1FGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2776436-B1 | NEW COMPOUNDS | ASTEX THERAPEUTICS LTD (GB) | 2019-03-13 | — | — | EP | disclosed |