Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | PARG | Q86W56 | 5/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20808953 | 0.84 | TSHR (0.46) | EGLN1LMNATRPA1ALDH1A1TSHR | |
| SCHEMBL20786948 | 0.82 | KDM4E (0.54) | LMNAKDM4EALDH1A1TSHRPARG | |
| SCHEMBL20808950 | 0.82 | EGLN1 (0.45) | EGLN1HSD17B10TSHRAKR1A1AKR1B1 | |
| SCHEMBL20808707 | 0.78 | EGLN1 (0.48) | EGLN1HSD17B10TSHRAKR1A1AKR1B1 | |
| SCHEMBL20786900 | 0.78 | EGLN1 (0.52) | EGLN1ALDH1A1TSHRAKR1A1AKR1B1 | |
| SCHEMBL20786896 | 0.77 | EGLN1 (0.41) | EGLN1LMNAHSD17B10ALDH1A1TSHR | |
| SCHEMBL31559468 | 0.76 | HSD17B10 (0.47) | EGLN1HSD17B10KDM4EALDH1A1 | |
| SCHEMBL20786876 | 0.76 | EGLN1 (0.40) | EGLN1LMNAHSD17B10TSHRPARG | |
| SCHEMBL20786885 | 0.74 | NPSR1 (0.41) | NPSR1LMNAHSD17B10KDM4EALDH1A1 | |
| SCHEMBL20786973 | 0.73 | PLK1 (0.41) | EGLN1HSD17B10ALDH1A1PARGTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3453707-B1 | BENZAZEPINE DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | SHANGHAI DE NOVO PHARMATECH CO LTD (CN) | 2022-02-16 | — | — | EP | disclosed |
| EP-3453707-A1 | BENZAZEPINE DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai de Novo Pharmatech Co., Ltd. (CN) | 2019-03-13 | — | — | EP | disclosed |