Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 8/20 | 0.55 |
| ▸ | ESR1 | P03372 | 6/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.38 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20813149 | 1.00 | ESR2 (0.55) | ESR2ESR1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL23368604 | 1.00 | ESR2 (0.55) | ESR2ESR1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL7888319 | 0.89 | ESR2 (0.69) | ESR2ESR1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL24495217 | 0.86 | ESR2 (0.46) | ESR2ESR1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL14140579 | 0.81 | ESR2 (0.55) | ESR2ESR1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL7184307 | 0.81 | ESR2 (0.55) | ESR2ESR1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL20739607 | 0.81 | ESR2 (0.55) | ESR2ESR1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL10692927 | 0.81 | ESR2 (0.55) | ESR2ESR1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL7184310 | 0.81 | ESR2 (0.55) | ESR2ESR1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL8029813 | 0.81 | SLC18A3 (0.56) | ESR2ESR1CYP2C9CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11701373-B2 | Substituted bicyclic compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-07-18 | — | — | US | disclosed |
| US-10709719-B2 | Substituted bicyclic compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-07-14 | — | — | US | disclosed |
| US-20190076450-A1 | SUBSTITUTED BICYCLIC COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2019-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11701373-B2 | Substituted bicyclic compounds | S1PR1, S1PR3, S1PR2 | ESR2 715/4885ESR1 1837/4885CYP2C9 3883/4885 |
| US-10709719-B2 | Substituted bicyclic compounds | S1PR1, S1PR3, S1PR2 | ESR2 715/4885ESR1 1837/4885CYP2C9 3883/4885 |
| US-20190076450-A1 | SUBSTITUTED BICYCLIC COMPOUNDS | S1PR1, S1PR3, S1PR2 | ESR2 715/4885ESR1 1837/4885CYP2C9 3883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.