Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 12/20 | 0.43 |
| ▸ | IDH1 | O75874 | 7/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL523461 | 1.00 | PLK1 (0.43) | PLK1IDH1BRD4BRDTMAPK8 | |
| SCHEMBL523126 | 1.00 | PLK1 (0.43) | PLK1IDH1BRD4BRDTMAPK8 | |
| SCHEMBL522682 | 0.89 | IDH1 (0.42) | PLK1IDH1BRD4BRDT | |
| SCHEMBL522943 | 0.89 | IDH1 (0.42) | PLK1IDH1BRD4BRDT | |
| SCHEMBL523913 | 0.89 | PLK1 (0.46) | PLK1IDH1BRD4BRDT | |
| SCHEMBL523096 | 0.89 | PLK1 (0.43) | PLK1IDH1BRD4BRDT | |
| SCHEMBL524087 | 0.89 | PLK1 (0.46) | PLK1IDH1BRD4BRDT | |
| SCHEMBL12694797 | 0.89 | PLK1 (0.43) | PLK1IDH1BRD4BRDT | |
| SCHEMBL522605 | 0.88 | IDH1 (0.45) | PLK1IDH1BRD4BRDT | |
| SCHEMBL522384 | 0.88 | IDH1 (0.45) | PLK1IDH1BRD4BRDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356122-B1 | PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2019-03-20 | — | — | EP | disclosed |