Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD51 | Q06609 | 16/20 | 0.78 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20816308 | 0.88 | RAD51 (1.00) | RAD51 | |
| SCHEMBL20836377 | 0.86 | RAD51 (0.78) | RAD51MEN1KMT2APTPN2PTPN1 | |
| SCHEMBL20816303 | 0.84 | RAD51 (1.00) | RAD51PTPN2PTPN1 | |
| SCHEMBL31612337 | 0.84 | RAD51 (0.72) | RAD51PTPN2PTPN1 | |
| SCHEMBL20816323 | 0.82 | RAD51 (1.00) | RAD51MEN1KMT2APTPN2PTPN1 | |
| SCHEMBL31612370 | 0.80 | RAD51 (0.68) | RAD51PTPN2PTPN1ADORA2A | |
| SCHEMBL29893229 | 0.80 | RAD51 (0.67) | RAD51MEN1KMT2APTPN2PTPN1 | |
| SCHEMBL20816316 | 0.80 | RAD51 (1.00) | RAD51MEN1KMT2APTPN2PTPN1 | |
| SCHEMBL20816317 | 0.80 | RAD51 (1.00) | RAD51 | |
| SCHEMBL20816322 | 0.80 | RAD51 (1.00) | RAD51 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10973819-B2 | Small molecules inhibitors of RAD51 | THE UNIVERSITY OF CHICAGO (US) | 2021-04-13 | — | — | US | disclosed |
| US-10973819-B2 | Small molecules inhibitors of RAD51 | THE UNIVERSITY OF CHICAGO (US) | 2021-04-13 | — | — | US | disclosed |
| US-20190083491-A1 | SMALL MOLECULES INHIBITORS OF RAD51 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-03-21 | — | — | US | disclosed |
| US-20190083491-A1 | SMALL MOLECULES INHIBITORS OF RAD51 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190083491-A1 | SMALL MOLECULES INHIBITORS OF RAD51 | RAD51, MRE11, DDB1 | RAD51 1/4885MEN1 1130/4885KMT2A 2002/4885 |
| US-10973819-B2 | Small molecules inhibitors of RAD51 | RAD51, MRE11, DDB1 | RAD51 1/4885MEN1 1130/4885KMT2A 2002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.