Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | ALKBH3 | Q96Q83 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20830325 | 0.91 | KDM4E (0.43) | ALDH1A1NPC1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL20830342 | 0.84 | KDM4E (0.52) | ALDH1A1NPC1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL20830169 | 0.82 | ABL1 (0.58) | KDM4EABL1RIN1ALKBH3 | |
| SCHEMBL11188532 | 0.68 | MAPT (1.00) | ALDH1A1NPC1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL20830289 | 0.68 | ABL1 (0.58) | ALDH1A1NPC1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL20819197 | 0.66 | ALKBH3 (0.62) | NPC1SMN1; SMN2RAB9AKDM4EALKBH3 | |
| SCHEMBL5032566 | 0.64 | HSP90AA1 (0.53) | ALDH1A1NPC1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL16938454 | 0.63 | BRD4 (0.61) | ALDH1A1NPC1SMN1; SMN2RAB9AMAPT | |
| Hydrochloric Acid SCHEMBL7324036 | 0.63 | HSP90AA1 (0.51) | ALDH1A1NPC1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL1170648 | 0.63 | KDM4E (0.61) | ALDH1A1NPC1SMN1; SMN2RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200308165-A1 | Compounds as Ras Inhibitors and Use Thereof | D. E. SHAW RESEARCH, LLC | 2020-10-01 | — | — | US | disclosed |
| US-20200308165-A1 | Compounds as Ras Inhibitors and Use Thereof | D. E. SHAW RESEARCH, LLC | 2020-10-01 | — | — | US | disclosed |
| EP-3681499-A1 | COMPOUNDS AS RAS INHIBITORS AND USE THEREOF | D.E. Shaw Research, LLC (US) | 2020-07-22 | — | — | EP | disclosed |
| WO-2019055540-A1 | COMPOUNDS AS RAS INHIBITORS AND USE THEREOF | D.E. SHAW RESEARCH, LLC (US) | 2019-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200308165-A1 | Compounds as Ras Inhibitors and Use Thereof | KRAS, NRAS, HRAS | ALDH1A1 2215/4885NPC1 1256/4885SMN1; SMN2 4018/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.