Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.53 |
| ▸ | POLB | P06746 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.53 |
| ▸ | RECQL | P46063 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20830335 | 0.81 | KDM4E (0.52) | KDM4EMAPTTDP1POLBMEN1 | |
| SCHEMBL20819194 | 0.72 | KDM4E (0.64) | KDM4EMAPTTDP1POLBMEN1 | |
| SCHEMBL22487735 | 0.71 | KDM4E (0.63) | KDM4EMAPTTDP1POLBMEN1 | |
| SCHEMBL20819221 | 0.71 | KDM4E (0.62) | KDM4EMAPTTDP1POLBMEN1 | |
| SCHEMBL20830297 | 0.70 | KDM4E (0.64) | KDM4EMAPTTDP1POLBMEN1 | |
| SCHEMBL15269986 | 0.68 | MAPT (0.67) | KDM4EMAPTTDP1POLBMEN1 | |
| SCHEMBL11108576 | 0.66 | KDM4E (0.67) | KDM4EMAPTTDP1POLBMEN1 | |
| SCHEMBL15233774 | 0.64 | KDM4E (1.00) | KDM4EMAPTTDP1POLBMEN1 | |
| SCHEMBL22487947 | 0.64 | KDM4E (0.53) | KDM4EMAPTTDP1POLBMEN1 | |
| SCHEMBL15269694 | 0.62 | KDM4E (0.73) | KDM4EMAPTTDP1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019055540-A1 | COMPOUNDS AS RAS INHIBITORS AND USE THEREOF | D.E. SHAW RESEARCH, LLC (US) | 2019-03-21 | — | — | WO | disclosed |