Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | CASP1 | P29466 | 2/20 | 0.54 |
| ▸ | KDM4A | O75164 | 1/20 | 0.54 |
| ▸ | KDM4B | O94953 | 1/20 | 0.54 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.54 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.54 |
| ▸ | ALKBH3 | Q96Q83 | 12/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALPL | P05186 | 1/20 | 0.51 |
| ▸ | ALPI | P09923 | 1/20 | 0.51 |
| ▸ | ALPG | P10696 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20819222 | 0.90 | KDM4E (0.59) | KDM4ETDP1L3MBTL1POLBALOX15 | |
| SCHEMBL20830148 | 0.89 | KDM4E (0.54) | KDM4ETDP1L3MBTL1POLBALOX15 | |
| SCHEMBL20830286 | 0.88 | KDM4E (0.55) | KDM4ETDP1L3MBTL1POLBALOX15 | |
| SCHEMBL20830336 | 0.88 | KDM4E (0.60) | KDM4ETDP1L3MBTL1POLBALOX15 | |
| SCHEMBL20830340 | 0.87 | KDM4E (0.56) | KDM4ETDP1L3MBTL1POLBALOX15 | |
| SCHEMBL20819227 | 0.87 | KDM4E (0.57) | KDM4ETDP1L3MBTL1POLBALOX15 | |
| SCHEMBL20819216 | 0.84 | KDM4E (0.53) | KDM4ETDP1L3MBTL1POLBALOX15 | |
| SCHEMBL20830285 | 0.84 | KDM4E (0.53) | KDM4ETDP1L3MBTL1POLBALOX15 | |
| SCHEMBL22463141 | 0.84 | KDM4E (0.49) | KDM4ETDP1L3MBTL1POLBALOX15 | |
| SCHEMBL20819201 | 0.84 | KDM4E (0.55) | KDM4ETDP1L3MBTL1POLBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019055540-A1 | COMPOUNDS AS RAS INHIBITORS AND USE THEREOF | D.E. SHAW RESEARCH, LLC (US) | 2019-03-21 | — | — | WO | disclosed |