SCHEMBL20835010

SCHEMBL20835010

CCCCCc1ccc(C#Cc2cc(C)c(SC#N)c(F)c2)c(CC)c1F

nearest known ligand 0.33

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 2/20 0.33
FFAR4 Q5NUL3 2/20 0.33
MEN1 O00255 1/20 0.32
TP53 P04637 1/20 0.32
CYP3A4 P08684 1/20 0.32
ALOX5 P09917 1/20 0.32
MAPT P10636 1/20 0.32
TYR P14679 1/20 0.32
ALOX15 P16050 1/20 0.32
TSHR P16473 1/20 0.32
HTT P42858 1/20 0.32
KMT2A Q03164 1/20 0.32
TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23309988 0.94 TYR (0.34) FFAR1FFAR4MEN1TP53CYP3A4
SCHEMBL23310015 0.91 TYR (0.33) FFAR1FFAR4TYR
SCHEMBL23310001 0.86 FFAR1 (0.33) FFAR1FFAR4
SCHEMBL20834704 0.81 FFAR1 (0.34) FFAR1FFAR4MAPTHTT
SCHEMBL20834944 0.80 MEN1 (0.32) FFAR1FFAR4MEN1TP53CYP3A4
SCHEMBL20834909 0.79 MEN1 (0.31) MEN1TP53CYP3A4ALOX5MAPT
SCHEMBL20835009 0.78 FFAR1 (0.33) FFAR1FFAR4MEN1TP53CYP3A4
SCHEMBL24940692 0.77 FFAR1 (0.35) FFAR1FFAR4ALOX5MAPTTSHR
SCHEMBL20834943 0.77 TYR (0.32) FFAR1FFAR4TYR
SCHEMBL24939923 0.76 FFAR1 (0.34) FFAR1FFAR4MEN1TP53CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019052972-A1 ISOTHIOCYANATO TOLANE DERIVATIVES MERCK PATENT GMBH (DE) 2019-03-21 WO disclosed