Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 12/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 10/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 10/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 9/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | INSR | P06213 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | YES1 | P07947 | 1/20 | 0.31 |
| ▸ | LYN | P07948 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | ROS1 | P08922 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | BCR | P11274 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19633267 | 0.95 | FGFR3 (0.38) | FGFR1FGFR3FGFR4FGFR2CYP3A4 | |
| SCHEMBL30745795 | 0.95 | FGFR3 (0.38) | FGFR1FGFR3FGFR4FGFR2CYP3A4 | |
| SCHEMBL26802384 | 0.92 | FGFR3 (0.37) | FGFR1FGFR3FGFR4FGFR2CYP3A4 | |
| SCHEMBL19633418 | 0.90 | FGFR1 (0.46) | FGFR1FGFR3FGFR4FGFR2CYP3A4 | |
| SCHEMBL26802454 | 0.89 | FGFR1 (0.46) | FGFR1FGFR3FGFR4FGFR2CYP3A4 | |
| SCHEMBL20836813 | 0.88 | FGFR1 (0.49) | FGFR1FGFR3FGFR4FGFR2 | |
| SCHEMBL30745818 | 0.87 | FGFR1 (0.45) | FGFR1FGFR3FGFR4FGFR2CYP3A4 | |
| SCHEMBL19633419 | 0.87 | FGFR1 (0.36) | FGFR1FGFR3FGFR4FGFR2CYP3A4 | |
| SCHEMBL19633409 | 0.86 | FGFR1 (0.42) | FGFR1FGFR3FGFR4FGFR2CYP3A4 | |
| SCHEMBL19633322 | 0.86 | FGFR1 (0.46) | FGFR1FGFR3FGFR4FGFR2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3459952-A1 | PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME AND USE THEREOF IN MEDICINE | Zhejiang Hisun Pharmaceutical Co., Ltd. (CN) | 2019-03-27 | — | — | EP | disclosed |