Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | C1S | P09871 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27917252 | 0.81 | IDO1 (0.43) | IDO1TDO2SLC6A2SLC6A4CYP3A4 | |
| SCHEMBL7605334 | 0.81 | IDO1 (0.47) | IDO1TDO2SLC6A2SLC6A4CYP3A4 | |
| SCHEMBL28795687 | 0.81 | IDO1 (0.43) | IDO1TDO2SLC6A2SLC6A4CYP3A4 | |
| SCHEMBL5858340 | 0.81 | IDO1 (0.43) | IDO1TDO2SLC6A2SLC6A4CYP3A4 | |
| SCHEMBL16962177 | 0.79 | IDO1 (0.46) | IDO1TDO2SLC6A2SLC6A4CYP3A4 | |
| SCHEMBL8130729 | 0.79 | ACP3 (0.44) | IDO1TDO2SLC6A2SLC6A4 | |
| SCHEMBL8257633 | 0.79 | SLC18A3 (0.44) | IDO1TDO2SLC6A2SLC6A4CYP3A4 | |
| SCHEMBL7786059 | 0.79 | ACP3 (0.44) | IDO1TDO2SLC6A2SLC6A4 | |
| SCHEMBL17660051 | 0.79 | SLC18A3 (0.44) | IDO1TDO2SLC6A2SLC6A4CYP3A4 | |
| SCHEMBL8779761 | 0.79 | ACP3 (0.44) | IDO1TDO2SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3731869-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2020-11-04 | — | — | EP | disclosed |
| EP-3684366-A1 | CRBN LIGANDS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2020-07-29 | — | — | EP | disclosed |
| WO-2019060693-A1 | CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2019-03-28 | — | — | WO | disclosed |