Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XPA | P23025 | 14/20 | 0.93 |
| ▸ | EP300 | Q09472 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | APEX1 | P27695 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.59 |
| ▸ | GSK3A | P49840 | 1/20 | 0.59 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.59 |
| ▸ | GALK1 | P51570 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20847921 | 1.00 | XPA (0.93) | XPAEP300MEN1APEX1KMT2A | |
| SCHEMBL20840287 | 1.00 | XPA (0.93) | XPAEP300MEN1APEX1KMT2A | |
| SCHEMBL19644002 | 0.96 | XPA (1.00) | XPAEP300MEN1APEX1KMT2A | |
| SCHEMBL19644519 | 0.96 | XPA (1.00) | XPAEP300MEN1APEX1KMT2A | |
| SCHEMBL19644003 | 0.96 | XPA (1.00) | XPAEP300MEN1APEX1KMT2A | |
| SCHEMBL19644222 | 0.94 | XPA (1.00) | XPAEP300MEN1APEX1KMT2A | |
| SCHEMBL19644204 | 0.94 | XPA (1.00) | XPAEP300MEN1APEX1KMT2A | |
| SCHEMBL19644205 | 0.94 | XPA (1.00) | XPAEP300MEN1APEX1KMT2A | |
| SCHEMBL20840271 | 0.92 | XPA (0.92) | XPAEP300MEN1APEX1KMT2A | |
| SCHEMBL19644352 | 0.92 | XPA (0.92) | XPAEP300MEN1APEX1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3684354-A1 | XPA INHIBITOR COMPOUNDS AND THEIR USE | Indiana University Research and Technology Corporation (US) | 2020-07-29 | — | — | EP | disclosed |
| WO-2019060260-A1 | XPA INHIBITOR COMPOUNDS AND THEIR USE | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2019-03-28 | — | — | WO | disclosed |